St. John’s wort’s action of mood modulation takes place at the synapsomal level where it works to inhibit the reuptake of three of the four known feel-good neurotransmitters. They are serotonin, norepinephrine and dopamine. Like many of the pharmaceuticals that inhibit the reuptake of only serotonin, this process can take up to 6 weeks to take effect. SJW works more gently and broadly and given that it effects three neurotransmitters is probably why it has such a low side effect profile.
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