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Table 3
Summary of studies on Hypericum Vs Placebo
| Authors year |
No |
substance |
dose |
Hamilton
start end |
Other
start end |
Resp rate |
Stat. sign. |
Side eff. |
Weeks |
drop outs |
Inclusion criteria |
Witte
1995
| 48
49
| Psychotonin
Placebo
| 0,5 mg x2 | 24.6 7.9
23 12
| 25 8
21 DS 12
| 79 %
56%
| p<
0.02
| 0
0
| 6 | 21%
total
| ICD10 F32.1 |
| Ditzler 1994 | 30
30
| Nerapas*
Placebo
| 0,24mgx3* | 15,3 7,3
18,4 DS 12,0
| 55,7 38,4
56,8 DSI 3,9
| 67%
33%
| p< 0,01 | No
diff
| 8 | 3%
0%
| DSM -III-R, major depression,
|
Sommer
1993
| 42
47
| Jarsin 300
Placebo
| 0,9 mg x 3 | 15.8 7.2
15.8 11,.3
| _ | 67%
28%
| p<
0.01
| No
diff
| 4 | 4%
14%
| ICD 09 300.4 309.0 |
Hubner
1993
| 20
19
| Jarsin 300
Placebo
| 0,9 mg x 3 | 12.5 5
12.4 11
| 15.8 6.8
16.7 HS 16.9
| 70%
47%
| p<
0.05
| No diff | 4
| _ | ICD 09 300.4 309.0
|
| König 1993 | 55
57
| extr. Z 90017
Placebo
| 0,5-1 mgx2 | 34,7 20,8
34,3 B-S 21,1
| 64,1 48,2
64,7 DSI 50,6
| 53%
53%
| no diff | 22%
28%
| 6 | 24%
26%
| Psychoaff. disorders with depressed mood
|
Hänsgen
1993
| 33
34
| Jarsin 300
Placebo
| 0,9 mg x 3 | 21.8 6
20.4 14
| 131 77
127 BEB 104
| 81%
26%
| p<
0.001
| 6%
3%
| 6 | 3%
12%
| DSM III R
major depression
|
| Lehrl 1993 | 25
25
| Jarsin
Placebo
| 0,37mg x 3 | 23,7 17,4
21,6 16,8
| 39,7 34,5
41,2 KAI 37,7
| 42%
25%
| no diff |
| 4 | ?
?
| ICD 09 300,4
309,0
|
Schmidt
1993
| 32
33
| Jarsin 300
Placebo
| 0.9 mg x 3 | ? ?
? ?
| No cognitive problems |
67%
27%
| p<
0.01
| 7%
10%
| 6 | 0%
| ICD 09 300,4
309,0
|
Martinez
1993
| 10
10
| Jarsin 300
+ light therapy
| 300 Lux
3000 Lux
| 20.6 8.2
21.9 6.1
| _ | _
| No
sign
| 0%
0%
| 4 | 0%
| DSM III R
SAD
|
| Quandt, 1993 | 88
| Psychotonin
Placebo
| 0,37mg x3 | 17.8 9.8
17.3 16.6
| - | 71%
7,7%
| p<
0.001
| 0%
0%
| 4 | ?
| ICD 09
300.4
|
| Osterheider 1992 | 22
2
| Psychotonin
Placebo
| 0,25mg x 3 | ? ?
? ?
| ? ?
? ?
| 0%
0%
| No diff | ?
| 8 | ?
| Unspecified
Depression
|
Reh,
1992
| 25
25
| Neuroplant
Placebo
| 0,5 mg x 2 | 19 8
20 14
| 30 9
32 D-S 22
| 80%
44%
| p< 0,02 | 0%
0%
| 8 | 0%
0%
| ICD 09 300.4
309.0 311.0
|
Harrer
1991
| 58
58
| Psychotonin
Placebo
| 0,37mg x 3 | 21,6 8,9
20,9 16,1
| 11,9 4,5
12,1 HAMA 8,2
| 75%
25%
| p<
0,001
| 2%
0%
| 6 | 6,4%
1,8%
| ICD 9 304,4
309,9
|
Halama
1991
| 25
25
| Jarsin
Placebo
| 0,37 mg | 18,0 10.0
17,5 18,0
| 30.0 12,5
30,0 B-L 29,5
| 50%
0%
| p<
0,005
| 4 %
0 %
| 4 | 0%
0%
| ICD 09 300,4
309,0
|
Schmidt
1989
| 16
12
| Psychotonin
Placebo
| 0,37mgx3 | 29,2 9,7
29,5 19,5
| 64.2 51,9
60,3 STAI 53,1
| 62,%
33,%
| p<
0,01
| 0%
0%
| 4 | 0%
0%
| ICD 09 290,2. 296,1 298,0. 300,0 300,4
|
Schlich
1987
| 22
24
| Psychotonin
Placebo
| 0,25mgx3 | 22,9 16,4
24,0 29,6
| 60,9 19,7
61,6 55,3
| 68%
10%
| p<
0,05
| 0%
0%
| 4 | 6%
total
| Unspecified depression
|
Hoffman
1979
| 30
30
| Hyperforat
Placebo
| 0,3mg x 3 | -
| 1,76 own 0,68
1,83 scale 1,54
| 61%
16%
| not
made
| 0%
0%
| 6 | 0%
0%
| mild to moderate
depression
|
D-S = Depression Scale according to von Zerssen,
self-rating, CGI = Clinical Global Impression score, HS = von
Zerssen Health Complaint survey, BEB = Symtom complaint inventory,
STAI = State Trait Anxiety Inventory, B-L = Beschwerden Liste
(Complaint Inventory) according to von Zerssen, HAMA = Hamilton
Anxiety scale, DSI = Depression Status Inventory * combination
medication with Hypericum, Valeria, Passiflorae, Coridalis cavae
and Eschscholixiae californiae
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